The Archbishop of Santiago de Chile is a Roman Catholic title given to the archbishop of the church in the Diocese of Santiago de Chile. From 1561 to 1840 the title was a bishop but since 1840 with Manuel Vicuña Larraín it was elevated to archbishop status.
| Number | Archbishop | Served |
| I | Monseñor Manuel Vicuña Larraín | 1840-1843 |
| II | Monseñor José Alejo Eyzaguirre Arechavala | 1844-1845 |
| III | Monseñor Rafael Valentín Valdivieso Zañartu | (1847-1878) |
| IV | Monseñor Mariano Casanova y Casanova | (1886-1908) |
| V | Monseñor Juan Ignacio González Eyzaguirre | (1908-1918) |
| VI | Monseñor Crescente José Errázuriz Valdivieso | 1918-1931 |
| VII | Monseñor José Horacio Campillo Infante | 1931-1939 |
| VIII | Cardenal José María Caro Rodríguez | 1939-1958 |
| IX | Cardenal Raúl Silva Henríquez | 1961-1983 |
| X | Cardenal Juan Francisco Fresno Larraín | 1983-1989 |
| XI | Cardenal Carlos Oviedo Cavada | 1989-1998 |
| XII | Cardenal Francisco Javier Errázuriz Ossa | 1998-2010 |
| XIII | Monseñor Ricardo Ezzati Andrello | 2010-present |